DOPE-Biotin

二油酰基磷脂酰乙醇胺改性生物素

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-Biotin

DOPE的伯氨基改性修饰成生物素活性基团

1,2-二油酰-SN-甘油-3-磷酰乙醇胺用途与合成方法生物活性

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE)是阳离子脂质体的中性辅助脂质(helperlipid)，与阳离子磷脂结合，提高裸siRNA的转染效率。
靶点IC50:helperlipidforliposome
体外研究

Inthisstudy,eachsiRNAisencapsulatedinLNP(cationiclipid-A:PEG2000-DMPE:DOPE=47.8:5.18:47.1molarpercent).WiththeneutrallipidfortheLNPisDOPE,LNPexertsknock-down(KD)effectonmacrophagesandDCsandLiposome-containingDOPEshowsfusogenicity.LNP/siRNAsignificantlysuppressesCD45proteinexpressionataninhibitionrateof30%onmacrophagesandDCsbutnotonmonocytes,neutrophils,plasmacytoidDCs,orBcells.LNPhasthepotentialtobeanefficientsiRNAdeliverysystemnotonlyformurinebutalsoforhumanmacrophagesandDCs.

纯度：大于98%
包装：瓶装
规格：mg与g级别
快递：顺丰，圆通，申通等
产地：西安
供应商：西安齐岳生物科技有限公司