Duocarmycin DM 是一种 DNA 小沟烷基化剂 (DNA minor-groove alkylator)，是一种抗体药物结合物 (ADCs) 毒素。Duocarmycin DM 因特有的结构而具有活性。
生物活性
Duocarmycin DM, a DNA minor-groove alkylator, is an antibody drug conjugates (ADCs) toxin. Duocarmycin DM is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity[1][2].

IC50 & Target
Daunorubicins/Doxorubicins

体外研究
(In Vitro)
The Duocarmycins and CC-1065 are members of a class of DNA minor groove, AT-sequence selective, and adenine-N3 alkylating agents, isolated from Streptomyces sp. that exhibit extremely potent cytotoxicity against the growth of cancer cells grown in culture[2].
Duocarmycin DM shows cytotoxicity to several human cancer cells, with IC50 of 22, 13.8, 3.87, 15.4, and 7.31 pM for HT-29, CL1-5, Caski, EJ, and LS174T, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量
577.98

Formula
C28H27ClF3N3O5

运输条件
Room temperature in continental US; may vary elsewhere.

储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
纯度：98%
用量：mg - kg
产地：西安
用途：科研
供应商：西安齐岳生物科技有限公司