常用名：(S,S,S)-AHPC hydrochloride

产品描述：

(S,S,S)-AHPC hydrochloride ((S,S,S)-VH032-NH2 hydrochloride) is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC. It is the VH032-based VHL ligand used in the recruitment of the VHL protein.

体外活性 VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.

别名 (S,S,S)-VH032-NH2 hydrochloride, (S,S,S)-AHPC盐酸盐

分子量 467.02

分子式 C22H31ClN4O3S

CAS No. 2115897-23-7

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: 99 mg/mL (211.98 mM), Sonication is recommended.

DMSO: 60 mg/mL (128.47 mM), Sonication is recommended.

PROteolysis TArgeting Chimeras (PROTACs) 通过将靶蛋白和 E3 连接酶结合起来，从而“劫持”细胞的泛素-蛋白酶体系统（UPS）来实现蛋白质的降解。由于 PROTACs 只需具有高选择性地结合其靶标（而不是抑制靶蛋白的酶活性），目前有许多努力将先前无效的抑制剂分子改造为 PROTACs，用作下一代药物。

产地：西安

用途：科研！

厂家：西安齐岳生物科技有限公司

温馨提示：仅用于科研，不能用于人体实验！

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