英文名称： SR-1114

产品描述 SR-1114, a first-in-class PROTAC ENL degrader, induces rapid CRBN-dependent ENL degradation with DC50 values of 150 nM in MV4;11 cells, 311 nM in MOLM-13 cells, and 1.65 μM in OCI/AML-2 cells [1].

MF： C39H42N8O11S

MW： 830.87

CAS： 2769141-82-2

密度：1.56±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

酸度系数(pKa)：7.13±0.50(Predicted)

体外活性 Certainly, here is a revised version of the sentence:

'Ser nM TPP nM CUR (7)' is a chemical compound that exhibits specific activity, engaging in targeted interactions within a designated chemical or biological context. The notation encapsulates its unique structure and function.

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体内活性 Ser nM TPP nM CUR (4 mg/kg; i.v. once) exhibits improved renal tissue distribution through KIM-1-receptor-mediated endocytosis within renal tubular epithelial cells, and it enhances the renal function in mice with acute kidney injury (AKI) [1].

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

PROteolysis TArgeting Chimeras (PROTACs) 通过将靶蛋白和 E3 连接酶结合起来，从而“劫持”细胞的泛素-蛋白酶体系统（UPS）来实现蛋白质的降解。由于 PROTACs 只需具有高选择性地结合其靶标（而不是抑制靶蛋白的酶活性），目前有许多努力将先前无效的抑制剂分子改造为 PROTACs，用作下一代药物。

产地：西安

用途：科研

厂家：西安齐岳生物科技有限公司

温馨提示：仅用于科研！

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