常用名：SJ1008030 formic

产品描述：

SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with an IC50 value of 5.4 nM. It is potentially applicable for leukemia research [1].

体外活性：

SJ1008030 (Compound 8) exhibits anti-cancer activity in the CRLF2r cell line (MHH-CALL-4) with an IC50 of 5.4 nM after 72 hours of treatment [1].

SJ1008030 (concentration range 0-4.3 μM; treatment time 72 hours) dose-dependently degrades JAK, GSPT1, and IKZF1 proteins in MHH-CALL-4 cells [1].

SJ1008030 (concentration range 0-10 μM; treatment time 24 hours) dose-dependently degrades JAK2 and GSPT1 proteins in xenograft bone marrow cells from SJBALL021415, demonstrating its potential to inhibit the JAK-STAT signaling pathway [1].

分子量 919.96

分子式 C43H45N13O9S

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

PROteolysis TArgeting Chimeras (PROTACs) 通过将靶蛋白和 E3 连接酶结合起来，从而“劫持”细胞的泛素-蛋白酶体系统（UPS）来实现蛋白质的降解。由于 PROTACs 只需具有高选择性地结合其靶标（而不是抑制靶蛋白的酶活性），目前有许多努力将先前无效的抑制剂分子改造为 PROTACs，用作下一代药物。

产地：西安

用途：科研

厂家：西安齐岳生物科技有限公司

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