抗体药物偶联物(ADC)的抗体靶点/连接臂的选择条件
西安齐岳生物提供不同结构和功能的多种连接子,可用于抗体和药物的偶联的连接子。我们可以将药物可控地偶联到抗体上,
抗体偶联药物(Antibody–drug conjugates (ADCs))可以定义为药物前体,抗体能够识别表达**抗原的靶点,并通过连接子与细胞*素的“弹头”偶联形成针对**细胞的靶向递送系统。
一个理想的ADC药物需要四个部分结合:
抗体(靶点)的选择:针对**特异(相关)性抗原,较高的表达水平,良好的内吞效率、良好的抗原亲和力、无免疫原性、药物可及性;
连接臂的选择:血液循环中保持稳定,在细胞内快速解体,释放*物;
连接方式:定点偶联,产生均一的抗体偶联物;
*素分子:一般要求*素足够强,达到单使用使IC50<1nmol;足够的水溶性及血清中的稳定性;*物的作用靶点位于细胞内。
抗体偶联药物结构模式
齐岳生物为客户提供不同规模的, 用于概念验证(POC)的抗体药物偶联物快速偶联服务。我们使用细胞*素,链接子和偶联方法的提供定制抗体药物偶联物服务。包括全面完整的抗体药物偶联物分析报告
擅长于Seattle Genetics方法偶联
基于半胱氨酸
擅长于Immunogen方法偶联
基于赖氨酸
提供完整的抗体药物偶联物表征分析方法:
分析工具:HPLC(HIC,SEC,RP),iCIEF,LC-MS
质量:药物与抗体比(DAR),通过SDS-PAGE分析的纯度,多聚体,内*素,药物残留
齐岳生物供应抗体偶联药物连接子目录:
产品名称 | 产品cas |
Fmoc-Val-Cit-PAB | CAS:cas:159858-22-7 |
Fmoc-Val-Cit-PAB-PNP | CAS:cas:863971-53-3 |
Val-cit-PAB-OH | CAS:159857-79-1 |
Phe-Lys(Trt)-PAB | CAS:1116085-99-4 |
Fmoc-Phe -Lys(Trt)-PAB-PNP | CAS:1116086-09-9 |
Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP | CAS:253863-34-2 |
Cbz‐Phe‐(Alloc)Lys‐PAB‐PNP | CAS:159857-90-6 |
Boc‐Phe‐(Alloc)Lys‐PAB‐PNP | CAS:1160844-44-9 |
N-SMP | CAS:55750‐61‐3 |
GMBS | CAS:80307-12-6 |
5-Maleimidovalericacid-NHS | CAS:103750-03-4 |
Mal-PEG4-NHS | CAS:1325208-25-0 |
Mal-PEG-NHS | CAS:1260092-50-9 |
5-hexynoic NHS ester | CAS:906564-59-8 |
NHS-PEG4-azide | CAS:944251-24-5 |
Bis-PEG1-NHS ester | CAS:65869-64-9 |
Bis-PEG2-NHS Ester | CAS:65869-63-8 |
Bis-PEG3-NHS Ester | CAS:1314378‐16‐9 |
NHS-PEG3-NHS | CAS:1314378-11-4 |
sulfo-LC-SPDP | CAS:150244‐18‐1 |
MAL-Tetra-EG-OPFP | CAS:1347750-84-8 |
Mal-PEG5-NHS | CAS:1315355-92-0 |
Mal-amido-PEG6-NHS | CAS:1137109-21-7 |
Maleimide-PEG8-NHS ester | CAS:756525-93-6 |
NHS-Ac-N3 | CAS:824426-32-6 |
NHS-PEG12-azide | CAS:1610796-02-5 |
Bis-PEG5-NHS ester | CAS:756526-03-1 |
Bis-PEG9-NHS ester | CAS:1008402-79-6 |
Boc-Val-Cit-PAB-PNP | CAS:870487-10-8 |
Alkyne-PEG-acid (PEG1-PEGn) | CAS:55683-37-9 |
Alkyne-PEG-NHS ester (PEG1-PEGn) | CAS:1174157-65-3 |
Alkyne-PEG-t-butyl ester (PEG1-PEGn) | CAS:488150-84-1 |
Alkyne-PEG-alcohol (PEG1-PEGn) | CAS:3973-18-0 |
Alkyne-PEG-bromide (PEG1-PEGn) | CAS:203740-63-0 |
Alkyne-PEG-Alkyne (PEG1-PEGn) | CAS:40842-04-4 |
Alkyne-PEG2-methylamine | CAS:1835759-76-6 |
Alkyne-PEG4-thiol | CAS:1347750-80-4 |
Alkyne-PEG4-5-nitrophenyl carbonate | CAS:1422540-81-5 |
Alkyne-PEG-methane (PEG1-PEGn) | CAS:89635-82-5 |
Alkyne-PEG4-(CH2)3-methyl ester | CAS:1872433-63-0 |
APN-C3-PEG4-alkyne | CAS:2183440-36-8 |
Alkyne-PEG2-acrylate | CAS:52436-42-7 |
Gly-PEG3-endo-BCN, TFA salt | CAS:2354291-37-3 |
Boc-Gly-PEG3-endo-BCN | CAS:2110444-63-6 |
Aminoethyl-SS-ethylalcohol | CAS:15579-01-8 |
Aminoethyl-SS-propionic acid | CAS:15579-00-7 |
Aminoethyl-SS-ethylamine | CAS:51-85-4 |
t-Boc-Cystamine | CAS:485800-26-8 |
N3-SS-PEG2-acid | CAS:2144777-72-8 |
N3-SS-propionic NHS ester | CAS:2243566-44-9 |
N3-SS-ethylalcohol | CAS:1807540-82-4 |
N3-SS-N3 | CAS:352305-38-5 |
N3-PEG3-SS-PEG3-N3 | CAS:1310827-27-0 |
N3-PEG2-t-Butyl ester | CAS:2144777-83-1 |
Alkyne-PEG1-SS-alcohol | CAS:1391914-41-2 |
Alkyne-PEG1-SS-PEG1-acid | CAS:1807503-85-0 |
Alkyne-PEG1-SS-PEG1-PFP ester | CAS:1817735-30-0 |
Alkyne-PEG1-SS-PEG1-Alkyne | CAS:1964503-40-9 |
Alkyne-PEG1-SS-PEG1-t-butyl ester | CAS:1807518-78-0 |
Acid-PEG-SS-PEG-acid (PEG1-PEGn) | CAS:1807539-10-1 |
Boc-NH-ethyl-SS-propionic acid | CAS:485800-27-9 |
Boc-aminooxy-ethyl-SS-propanol | CAS:2128735-21-5 |
Fmoc-NH-ethyl-SS-propionic acid | CAS:864235-83-6 |
Fmoc-NH-ethyl-SS-propionic NHS ester | CAS:2128735-23-7 |
Mal-NH-ethyl-SS-propionic acid | CAS:2128735-24-8 |
Hydroxy-PEG3-SS-PEG3-alcohol | CAS:5662-81-7 |
THP-SS-alcohol | CAS:877864-04-5 |
THP-SS-PEG1-t-butyl ester | CAS:1807503-88-3 |
THP-SS-PEG1-Tos | CAS:1807512-37-3 |
2-hydroxyethyl disulfide mono-Tosylate | CAS:1807530-16-0 |
Bis-Tos-(2-hydroxyethyl disulfide) | CAS:69981-39-1 |
N3-SS-biotin | CAS:1620523-64-9 |
DBCO-SS-PEG3-biotin | CAS:1430408-09-5 |
Biotin-bisamido-SS-NHS | CAS:142439-92-7 |
NHS-SS-biotin | CAS:122266-55-1 |
Sulfo-NHS-SS-biotin | CAS:325143-98-4 |
PC Biotin-PEG3-alkyne | CAS:1869922-24-6 |
PC Biotin-PEG3-N3 | CAS:1937270-46-6 |
PC Biotin-PEG3-NHS carbonate ester | CAS:2353409-93-3 |
PC Alkyne-PEG4-NHS carbonate ester | CAS:1802907-98-7 |
PC Methyltetrazine-PEG4-NHS carbonate ester | CAS:1408057-91-9 |
PC N3-PEG11-NHS carbonate ester | CAS:2353409-91-1 |
Mal-PEG2-Val-Cit-PAB-OH | CAS:2055041-38-6 |
Mal-PEG1-Val-Cit-PAB-PNP | CAS:2249935-92-8 |
Mal-amido-PEG2-Val-Cit-PAB-PNP | CAS:2112738-13-1 |
N3-PEG3-Val-Cit-PAB-OH | CAS:2055024-65-0 |
N3-PEG3-Val-Cit-PAB-PNP | CAS:2055047-18-0 |
BCN-PEG3-VC-PFP Ester | CAS:2353409-45-5 |
Methylamino-PEG-acid (PEG1-PEGn) | CAS:1367918-21-5 |
厂家:西安齐岳生物科技有限公司
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