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Amine-PEG-Thiol 1347750-20-2 氨基-聚乙二醇-巯基 NH2-PEG-SH
发布时间:2023-05-26     作者:LYQ   分享到:

巯基PEG氨基(HS-PEG-NH2)可用于蛋白质的修饰、多肽等物质或小分子等。

英文名称:Amine-PEG-Thiol

中文名称:氨基-聚乙二醇-巯基

CAS:1347750-20-2

英文别名:Amine-PEG-SH;NH2-PEG-SH;NH2-PEG-Thiol

产品说明:

氨基(-NH2)能方便地与羧基牢固生成酰胺键,还可与活性酯(-NHS)在PH7-8.5形成酰胺键。巯基(-SH)与马来酰亚胺以及在PH6.5-7.5之间极易生成稳定硫醚键。硫醇基团与金表面亲和性较高,用于金纳米颗粒或金膜改性。PEG修饰可以增加溶解度,稳定性好,还可以抑制修饰表面带电分子的非特异性结合。

结构式:

Amine-PEG-Thiol

Amino group (- NH2) can easily and firmly form amide bond with carboxyl group, and can also form amide bond with active ester (- NHS) in PH7-8.5. Sulfhydryl (- SH) and maleimide, as well as between PH6.5-7.5, are very easy to generate stable thioether bonds. Mercaptan group has high affinity with gold surface, and is used for modification of gold nanoparticles or gold films. PEG modification can increase the solubility and stability, and can also inhibit the non-specific binding of charged molecules on the modified surface.

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