中文名称：二苯并环辛炔-聚乙二醇-3-(2-吡啶二硫代)丙酸N-羟基琥珀酰亚胺酯

英文名称：DBCO-PEG-SPDP；SPDP-PEG-DBCO

Product description:

SPDP first reacts with a protein molecule via its amino group. SPDP introduces pyridine disulfide into the protein, and then the pyridine disulfide is reduced by DTT to form mercaptan group. These mercaptan groups then form a disulfide bond with another protein molecule to produce heterodimer proteins.

SPDP结构式：

DBCO (dibenzocyclooctene) is a cycloalkyne, which can react with azide through 1,3-dipolar cycloaddition promoted by strain in aqueous solution, which is a biorthogonal reaction, also known as copper free click reaction. The selectivity and biocompatibility of this reaction enable complementary reagents to form covalent bonds with functional biological systems. Copper free click reaction is a powerful tool for biocoupling without catalyst. DBCO reagent has fast kinetics and stability in water buffer, and can be used to label azide modified biomolecules with high specificity and reactivity.

外观：固体或粘性液体，取决于分子量

端基取代率：≥95%

用途：仅用于科学研究或者工业应用等非医疗目的，非药用，非食用

注意事项：取用一定要干燥，避免频繁的溶解和冻干

溶解性：溶于大部分有机溶剂，如：DCM、DMF、DMSO、THF等等。在水中有很好的溶解性

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