活性氧MCB-613，296792-62-6，4-ethyl-2,6-bis(3-pyridinylmethylene)-cyclohexanone-UDP糖丨MOF丨金属有机框架丨聚集诱导发光丨推荐西安齐岳生物 -

The p160 steroid receptor coactivator (SRC) family, SRC-1/NCOA1, SRC-2/NCOA2/TIF2/GRIP1, and SRC-3/NCOA3/AIB1/RAC3/ACTR/pCIP, interact with nuclear receptors and other transcription factors to drive target gene expression and integrate growth signaling pathways on which cancer cells rely. MCB-613 is a small molecule stimulator of SRC-1, SRC-2, and SRC-3 that has been used to disrupt cancer cell homeostatic dependence on SRCs.1 MCB-613 can increase the interaction of SRCs with the coactivators CBP and CARM1 and can induce ER stress coupled to the generation of reactive oxygen species.1 Overactivation of SRCs by 1-7 µM MCB-613 was shown to selectively and dose dependently induce paraptosis in a variety of cancer cells in vitro but not in normal cells.1 At 20 mg/kg, MCB-613 was also shown to inhibit tumor growth in an MCF-7 breast cancer xenograft model in mice.1

活性氧MCB-613，296792-62-6，4-ethyl-2,6-bis(3-pyridinylmethylene)-cyclohexanone