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8种常见抗体药物偶联物(ADC)的不良反应及注意事项
发布时间:2021-04-07     作者:axc   分享到:

抗体**偶联物(antibody-drug conjugate,ADC)是一类通过连接头将靶标特异性的单克隆抗体与细胞*性药物偶联起来的靶向生物药物,以单克隆抗体为载体将小分子细胞**以靶向方式运输至目标**细胞中。

目前已有8种ADC药物(表1)。

                                           表1 ADC**

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抗体-药物偶联物(ADC产品目录

产品cas号产品名称
cas:159858-22-7Fmoc-Val-Cit-PAB
cas:863971-53-3Fmoc-Val-Cit-PAB-PNP
cas:55750-63-56-Maleimidohexanoic acid N-hydroxysuccinimide ester
cas:159857-79-1Val-cit-PAB-OH
cas:1116085-99-4Phe-Lys(Trt)-PAB
cas:1116086-09-9Fmoc-Phe -Lys(Trt)-PAB-PNP
cas:159857-79-1Val-Cit-PAB
cas:253863-34-2Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP
cas:159857-90-6Cbz‐Phe‐(Alloc)Lys‐PAB‐PNP
cas:1160844-44-9Boc‐Phe‐(Alloc)Lys‐PAB‐PNP
cas:55750‐61‐3N-SMP
cas:103750-03-45-Maleimidovalericacid-NHS
cas:1325208-25-0Mal-PEG4-NHS
cas:1260092-50-9Mal-PEG-NHS
cas:756525-99-2Mal-PEG4-NHS-ester
cas:1263044-56-9MC-PEG2-C2-NHS ester
cas:132178-37-14-pentynoic acid succinimidyl ester
cas:906564-59-85-hexynoic NHS ester
cas:944251-24-5NHS-PEG4-azide
cas:65869-64-9Bis-PEG1-NHS ester
cas:65869-63-8Bis-PEG2-NHS Ester
cas:1314378‐16‐9Bis-PEG3-NHS Ester
cas:1314378-11-4NHS-PEG3-NHS
cas:150244‐18‐1sulfo-LC-SPDP
cas:1347750-84-8MAL-Tetra-EG-OPFP
cas:1315355-92-0Mal-PEG5-NHS
cas:1137109-21-7Mal-amido-PEG6-NHS
cas:756525-93-6
cas:1137109-22-8Mal-PEG10-NHS
cas:824426-32-6Aeide-C1-NHS ester
cas:1610796-02-5NHS-PEG12-azide
cas:756526-03-1Bis-PEG5-NHS ester
cas:1008402-79-6Bis-PEG9-NHS ester
cas:870487-10-8Boc-Val-Cit-PAB-PNP
cas:55683-37-9Propargyl-PEG1-acid
cas:1174157-65-3Propargyl-PEG1-NHS ester
cas:488150-84-1Propargyl-PEG1-Boc
cas:3973-18-0Propynol Ethoxylate
cas:203740-63-0Propargyl-PEG3-bromide
cas:40842-04-4Bis-propargyl-PEG1
cas:1835759-76-6Alkyne-PEG2-methylamine
cas:1347750-80-4Alkyne-PEG4-thiol
cas:1422540-81-5Alkyne-PEG4-5-nitrophenyl carbonate
cas:89635-82-5Propargyl-PEG3-methane
cas:1872433-63-0Alkyne-PEG4-(CH2)3-methyl ester
cas:2183440-36-8APN-C3-PEG4-alkyne
cas:52436-42-7Alkyne-PEG2-acrylate
cas:2354291-37-3Gly-PEG3-endo-BCN, TFA salt
cas:2110444-63-6Boc-Gly-PEG3-endo-BCN
cas:15579-01-8Aminoethyl-SS-ethylalcohol
cas:15579-00-7Aminoethyl-SS-propionic acid
cas:51-85-4Aminoethyl-SS-ethylamine
cas:485800-26-8t-Boc-Cystamine
cas:2228857-32-5N3-SS-propionic acid
cas:2144777-72-8N3-SS-PEG2-acid
cas:2243566-44-9N3-SS-propionic NHS ester
cas:1807540-82-4N3-SS-ethylalcohol
cas:352305-38-5N3-SS-N3
cas:1310827-27-0N3-PEG3-SS-PEG3-N3
cas:2144777-83-1N3-PEG2-t-Butyl ester
cas:1391914-41-2Alkyne-PEG1-SS-alcohol
cas:1807503-85-0Alkyne-PEG1-SS-PEG1-acid
cas:1817735-30-0Alkyne-PEG1-SS-PEG1-PFP ester
cas:1964503-40-9Alkyne-PEG1-SS-PEG1-Alkyne
cas:1807518-78-0Alkyne-PEG1-SS-PEG1-t-butyl ester
cas:1807539-10-1Acid-PEG-SS-PEG-acid
cas:485800-27-9Boc-NH-ethyl-SS-propionic acid
cas:2128735-21-5Boc-aminooxy-ethyl-SS-propanol
cas:864235-83-6Fmoc-NH-ethyl-SS-propionic acid
cas:2128735-23-7Fmoc-NH-ethyl-SS-propionic NHS ester
cas:2128735-24-8Mal-NH-ethyl-SS-propionic acid
cas:5662-81-7Hydroxy-PEG3-SS-PEG3-alcohol
cas:877864-04-5THP-SS-alcohol
cas:1807503-88-3THP-SS-PEG1-t-butyl ester
cas:1807512-37-3THP-SS-PEG1-Tos
cas:1807530-16-02-hydroxyethyl disulfide mono-Tosylate
cas:69981-39-1Bis-Tos-(2-hydroxyethyl disulfide)
cas:1620523-64-9N3-SS-biotin
cas:1430408-09-5DBCO-S-S-PEG3-biotin
cas:142439-92-7Biotin-bisamido-SS-NHS
cas:122266-55-1NHS-SS-biotin
cas:325143-98-4Sulfo-NHS-SS-biotin
cas:1869922-24-6PC Biotin-PEG3-alkyne
cas:1937270-46-6PC Biotin-PEG3-N3
cas:2353409-93-3PC Biotin-PEG3-NHS carbonate ester
cas:1802907-98-7PC Alkyne-PEG4-NHS carbonate ester
cas:1408057-91-9PC Methyltetrazine-PEG4-NHS carbonate ester
cas:2353409-91-1PC N3-PEG11-NHS carbonate ester
cas:2055041-38-6Mal-PEG2-Val-Cit-PAB-OH
cas:Mal-PEG1-Val-Cit-PAB-PNP
cas:2112738-13-1Mal-amido-PEG2-Val-Cit-PAB-PNP
cas:2055024-65-0N3-PEG3-Val-Cit-PAB-OH
cas:2055047-18-0N3-PEG3-Val-Cit-PAB-PNP
cas:2353409-45-5BCN-PEG3-VC-PFP Ester
cas:1367918-21-5Methylamino-PEG1-acid
cas:1807521-03-4Methylamino-PEG1-Boc
cas:1355197-57-7Methylamino-PEG-N3 (PEG1-PEGn)
cas:85475-01-0Methylamino-PEG-Hydroxy (PEG1-PEGn)
cas:2279944-69-1N,N'-DME-N-PEG2-tert-butyl ester
cas:1817735-39-9N3-PEG2-sulfonic acid
cas:255831-16-4Sulfonic acid-PEG3-sulfonic acid
cas:112724-27-3Hydroxy-PEG2-C2-sulfonic acid
cas:787524-78-1m-PEG4-sulfonic acid
cas:1817735-29-7Sulfonic acid-PEG4-alkyne
cas:1817735-32-2Boc-NH-PEG3-sulfonic acid
cas:1817735-40-2Sulfonic acid-PEG2-t-Butoxycarbonyl
cas:144942-89-2Amino-PEG-acid (PEG1-PEGn)
cas:134978-97-5Amino-PEG-CH2COOH (PEG1-PEGn)
cas:1263046-77-0Amino-PEG-(CH2)3COOH (PEG1-PEGn)
cas:1260092-46-3Amino-PEG-t-butyl ester (PEG1-PEGn)
cas:929-06-6Amino-PEG-alcohol (PEG1-PEGn)
cas:2752-17-2Amino-PEG-Amine (PEG1-PEGn)
cas:464190-91-8Amino-PEG-N3 (PEG1-PEGn)
cas:1835759-88-0N3-PEG-methylamine (PEG1-PEGn)
cas:1817735-43-5Amino-PEG-sulfonic acid (PEG1-PEGn)
cas:2100306-60-1Amino-PEG-t-Boc-Hydrazide (PEG1-PEGn)
cas:31576-51-9Amino-PEG-methyl (PEG1-PEGn)
cas:122116-12-5Alkyne-PEG-amine (PEG1-PEGn)
cas:1835759-76-6Propargyl-PEG2-methylamine
cas:127828-22-2t-Boc-N-Amido-PEG-amine (PEG1-PEGn)
cas:1351397-21-1Amino-PEG-benzyl ester (PEG1-PEGn)
cas:1872433-72-1Trifluoroethyl-PEG-Amine (PEG1-PEGn)
cas:2110448-97-8Gly-PEG-amine (PEG1-PEGn)
cas:1020112-73-52-Amino-1,3-bis(carboxylethoxy)propane HCl salt
cas:2055042-59-4N-(Amino-PEG3)-N-bis(PEG3-acid) HCl salt
cas:2183440-35-7N-(acid-PEG3)-N-bis(PEG3-amine)
cas:2183440-70-0N-(N3-PEG3)-N-(PEG2-amine)-PEG3-acid
cas:174362-95-9Amino-Tri-(carboxyethoxymethyl)-methane
cas:2100306-47-4N-(Amino-PEG1)-N-bis(PEG2-alkyne) HCl salt
cas:2055040-99-6N-(Mal-PEG6)-N-bis(PEG3-amine) TFA salt

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